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Proteintech
WDR5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
15544-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
WDR5 Fusion Protein Ag7900 (1-334 aa encoded by BC001635)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.13 mg/mL
规格
19.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The WDR5 antibody targets the WD repeat protein domain 5 (WDR5), a member of the WD40 repeat protein family in humans.
Immunogen sequence: MATEEKKPE TEAARAQPTP SSSATQSKPT PVKPNYALKF TLAGHTKAVS SVKFSPNGEW LASSSADKLI KIWGAYDGKF EKTISGHKLG ISDVAWSSDS NLLVSASDDK TLKIWDVSSG KCLKTLKGHS NYVFCCNFNP QSNLIVSGSF DESVRIWDVK TGKCLKTLPA HSDPVSAVHF NRDGSLIVSS SYDGLCRIWD TASGQCLKTL IDDDNPPVSF VKFSPNGKYI LAATLDNTLK LWDYSKGKCL KTYTGHKNEK YCIFANFSVT GGKWIVSGSE DNLVYIWNLQ TKEIVQKLQG HTDVVISTAC HPTENIIASA ALENDKTIKL WKSDC (1-334 aa encoded by BC001635)
靶标信息
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BMP-2-induced gene 3 kb; BMP2-induced 3-kb gene protein; cilia and flagella associated protein 89; SWD3, Set1c WD40 repeat protein, homolog; unnamed protein product; WD repeat-containing protein 5-like; WD repeat-containing protein BIG-3
基因别名: 2410008O07Rik; Big; BIG-3; BIG3; CFAP89; SWD3
UniProt ID: (Human) P61964, (Rat) Q498M4, (Mouse) P61965
Entrez Gene ID: (Human) 11091, (Rat) 362093, (Mouse) 140858
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
peptidyl-lysine methylation
neuron projection development
positive regulation of gluconeogenesis
positive regulation of gene expression, epigenetic
regulation of embryonic development
regulation of cell division
regulation of cell cycle
regulation of tubulin deacetylation
positive regulation of transcription, DNA-templated
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