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Invitrogen
WHIP Polyclonal Antibody
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WHIP Antibody (PA1-29543) in WB
Western blot analysis is shown using GeneTex Affinity Purified anti-Human WHIP Polyclonal Antibody (Product # PA1-29543) to detect Human WHIP present in a HEK293 whole cell lysate. ~30 mg of lysate was loaded per lane for 4-20% gradient SDS-PAGE. Comparison to a molecular weight marker (not shown) indicates a primary band of ~96.0 kDa is detected. The identity of the minor band migrating at a slightly higher molecular weight is unknown, but may represent an alternate isoform of WHIP or post translational modification of the WHIP protein. T... View More
产品信息
PA1-29543
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide SRESYDAPPTPSGAC conjugated to KLH, corresponding to amino acids 107-120 of Human WHIP.
偶联物
形式
Liquid
浓度
0.42 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-29543 detects WHIP from human samples.
PA1-29543 has been successfully used in Western blot applications.
The PA1-29543 immunogen is: Synthetic peptide: SRESYDAPPTPSGAC conjugated to KLH, corresponding to amino acids 107-120 of Human WHIP.
靶标信息
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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