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Invitrogen
WNT1 Polyclonal Antibody
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产品信息
PA1-20993
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminal region of the human protein.
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
4°C, do not freeze
运输条件
Wet ice
RRID
产品详细信息
PA1-20993 detects Wnt1 in Human, Mouse and Rat samples.
PA1-20993 has been successfully used in Immunohistochemistry (Paraffin) and Western Blot procedures. For immunohistochemistry (paraffin) applications, boil tissue sections in 10 mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes. The predicted molecular weight of PA1-20993 is 41 kDa.
PA1-20993 immunogen corresponds to Synthetic peptide corresponding to the N-terminal region of the human protein.
靶标信息
Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal. The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor. Extensive research has shown that deregulation of these pathways or its components can lead to cancer. Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form. At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1. Depending on the tissue, Wnt-1 can activate the canonical and non-canonical signaling pathways. Studies have demonstrated its involvement in a variety of functions, including embryonic development and carcinogenesis. Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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