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Proteintech
WRNIP1 Polyclonal Antibody
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产品信息
16238-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
WRNIP1 Fusion Protein Ag9040 (293-640 aa encoded by BC018923)
偶联物
形式
Liquid
浓度
0.38 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: VTLSATNAK TNDVRDVIKQ AQNEKSFFKR KTILFIDEIH RFNKSQQVNA ALLSRCRVIV LEKLPVEAMV TILMRAINSL GIHVLDSSRP TDPLSHSSNS SSEPAMFIED KAVDTLAYLS DGDARAGLNG LQLAVLARLS SRKMFCKKSG QSYSPSRVLI TENDVKEGLQ RSHILYDRAG EEHYNCISAL HKSMRGSDQN ASLYWLARML EGGEDPLYVA RRLVRFASED IGLADPSALT QAVAAYQGCH FIGMPECEVL LAQCVVYFAR APKSIEVYSA YNNVKACLRN HQGPLPPVPL HLRNAPTRLM KDLGYGKGYK YNPMYSEPVD QEYLPEELRG VDFFKQRRC (293-640 aa encoded by BC018923)
靶标信息
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase WRNIP1; FLJ22526; putative helicase RUVBL; RP11-420G6.2; Werner helicasae interacting protein 1; Werner helicase-interacting protein 1; Werner syndrome homolog interacting protein; WRNIP1; wrnip1 {ECO:0000250|UniProtKB:Q96S55}
基因别名: 4833444L21Rik; bA420G6.2; WHIP; Wrnip; WRNIP1
UniProt ID: (Human) Q96S55, (Rat) Q8CG07, (Mouse) Q91XU0
Entrez Gene ID: (Human) 56897, (Rat) 282835, (Mouse) 78903
