PA1-38864 detects Wilms Tumor from human samples. Expected to cross react with mouse and rat samples due to sequence homology.

PA1-38864 has been successfully used in immunohistochemistry (paraffin) applications. Antigen retrieval requires boiling tissue sections in 10 mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes. Positive control of Wilm's tumor suggested.

The PA1-38864 immunogen is a synthetic peptide corresponding to the C-terminus of human Wilm's Tumor.

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The Wilms Tumor 1 gene encodes one of the WPP domain-interacting proteins (Wilms Tumor 1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). Wilms Tumor 1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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WT1 Polyclonal Antibody

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PA1-38864

免疫组化（石蜡） (IHC (P))

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