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Invitrogen
XPA Polyclonal Antibody
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产品信息
PA5-80236
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human XPA.
偶联物
形式
Lyophilized
浓度
500 µg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
The synthetic peptide sequence is 174-208aa, QWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQ
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
靶标信息
The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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