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Invitrogen
XPB Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-76038
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human XPB.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The human XPB DNA helicase is a subunit of the DNA repair/basal transcription factor TFIIH, and is involved in early steps of the nucleotide excision repair (NER) pathway. Two distinct clinical phenotypes, xeroderma pigmentosum associated with Cockayne's syndrome (XP/CS) and trichothiodystrophy (TTD), can be due to mutations in the XPB gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2-p89; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; excision repair 3; General transcription and DNA repair factor IIH helicase/translocase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB; Xeroderma pigmentosum group B-complementing protein
基因别名: BTF2 p89; Ercc-3; ERCC3; XPB; XPBC
UniProt ID: (Mouse) P49135
Entrez Gene ID: (Mouse) 13872
nucleotide binding
DNA binding
ATP-dependent DNA helicase activity
helicase activity
protein kinase activity
ATP binding
GTP binding
protein C-terminus binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
hydrolase activity
ATPase activity
dATP binding
peptide binding
3'-5' DNA helicase activity
protein N-terminus binding
DNA metabolism protein
DNA helicase
nucleic acid metabolism protein
nucleotide-excision repair, DNA duplex unwinding
DNA topological change
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
protein localization
response to UV
UV protection
nucleotide-excision repair, DNA incision
hair cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
regulation of mitotic cell cycle phase transition
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