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Invitrogen
XPB Polyclonal Antibody
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XPB Antibody (PA5-95556) in WB
Western blot analysis of XPB in Lane 1: rat testis tissue lysates, Lane 2: mouse testis tissue lysates. Electrophoresis was performed with 5-20% SDS-PAGE gel (70V, Stacking gel; 90V Resolving gel, Time: 2-3 hours), transferred to a nitrocellulose membrane and blocked using 5% Non-fat Milk/TBS (1.5 hrs at room temperature). Samples were incubated with XPB polyclonal antibody (Product # PA5-95556) using a 0.5 µg/mL dilution, followed by a goat anti-rabbit IgG-HRP at a dilution of 1:10,000, and developed with enhanced chemiluminescence (ECL).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95556
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human XPB recombinant protein (Position: Q665-K715).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat testis tissue, mouse testis tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
The human XPB DNA helicase is a subunit of the DNA repair/basal transcription factor TFIIH, and is involved in early steps of the nucleotide excision repair (NER) pathway. Two distinct clinical phenotypes, xeroderma pigmentosum associated with Cockayne's syndrome (XP/CS) and trichothiodystrophy (TTD), can be due to mutations in the XPB gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2-p89; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; excision repair 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; General transcription and DNA repair factor IIH helicase/translocase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB; Xeroderma pigmentosum group B-complementing protein
基因别名: BTF2 p89; Ercc-3; Ercc3; XPB; Xpbc
UniProt ID: (Mouse) P49135, (Rat) Q4G005
Entrez Gene ID: (Mouse) 13872, (Rat) 291703
nucleotide binding
DNA binding
ATP-dependent DNA helicase activity
helicase activity
protein kinase activity
ATP binding
GTP binding
protein C-terminus binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
hydrolase activity
ATPase activity
dATP binding
peptide binding
3'-5' DNA helicase activity
protein N-terminus binding
protein binding
transcription factor binding
DNA metabolism protein
DNA helicase
nucleic acid metabolism protein
nucleotide-excision repair, DNA duplex unwinding
DNA topological change
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
protein localization
response to UV
UV protection
nucleotide-excision repair, DNA incision
hair cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
regulation of mitotic cell cycle phase transition
response to hypoxia
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