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OriGene
XRN2 Monoclonal Antibody (OTI5F4), TrueMAB™
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产品信息
CF809427
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
OTI5F4
抗原
Human recombinant protein fragment corresponding to amino acids 677-779 of human XRN2 produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
XRN2 gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein; Protein Dhm1; XRN2b
基因别名: Dhm1; XRN2
UniProt ID: (Human) Q9NXS6, (Mouse) Q9DBR1
Entrez Gene ID: (Human) 22803, (Mouse) 24128, (Rat) 362229
3'-5'-exoribonuclease activity
transcription termination site sequence-specific DNA binding
nuclease activity
5'-3' exoribonuclease activity
protein binding
5'-3' exonuclease activity
poly(A) RNA binding
metal ion binding
nucleic acid binding
DNA binding
exonuclease activity
zinc ion binding
hydrolase activity
molecular_function
exoribonuclease
DNA catabolic process, exonucleolytic
DNA-templated transcription, termination
regulation of transcription, DNA-templated
rRNA processing
RNA processing
mRNA processing
RNA catabolic process
spermatogenesis
cell growth
RNA metabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
nucleobase-containing compound metabolic process
DNA repair
DNA recombination
transcription, DNA-templated
microtubule-based process
biological_process
