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Invitrogen
ZCCHC4 Polyclonal Antibody
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ZCCHC4 Antibody (PA5-87672) in WB
Western blot analysis of ZCCHC4 in mouse kidney. Samples were incubated with ZCCHC4 Polyclonal antibody (Product # PA5-87672) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-87672
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 50-220 of human ZCCHC4 (NP_0792122)
偶联物
形式
Liquid
浓度
1.35 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KVTQGKEETR RFYACSACRD RKDCNFFQWE DEKLSGARLA AREAHNRRCQ PPLSRTQCVE RYLKFIELPL TQRKFCQTCQ QLLLPDDWGQ HSEHQVLGNV SITQLRRPSQ LLYPLENKKT NAQYLFADRS CQFLVDLLSA LGFRRVLCVG TPRLHELIKL TASGDKKSNI K; Positive Samples: Mouse kidney
靶标信息
The ZCCHC4 gene encodes zinc finger CCHC domain-containing protein 4, a member of the zinc finger CCHC-type (ZCCHC) superfamily characterized by a consensus sequence C-X2-C-X4-H-X4-C. This gene plays a vital role in binding single-stranded nucleic acids, particularly RNAs, and is involved in multiple cellular processes. Notably, ZCCHC4 has been implicated in cancer, with aberrantly high expression linked to poor prognosis and chemoresistance in various cancers, including hepatocellular carcinoma, pancreatic cancer, colon cancer, and esophageal cancer. The protein exhibits RNA-modifying capabilities, influencing cell growth and survival. Recent studies have identified the structural mechanisms through which ZCCHC4 interacts with RNA substrates, offering insights into its role in regulating cancer progression and therapeutic resistance. In esophageal cancer, downregulation of ZCCHC4 may enhance sensitivity to chemotherapeutic agents like cisplatin, indicating its potential as a target for cancer treatment strategies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: rRNA N(6)-adenosine-methyltransferase ZCCHC4; Zinc finger CCHC domain-containing protein 4
基因别名: 4930449I23Rik; Zcchc4
UniProt ID: (Mouse) Q8BKW4
Entrez Gene ID: (Mouse) 78796
