Bioss

ZEB1/2 Polyclonal Antibody

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

BS-4187R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

流式细胞分析 (Flow)

1:100
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human ZEB1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

ZEB1 Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. ZEB2 is a Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Delta EF1; delta-crystallin enhancer binding factor 1; MEB1; Negative regulator of IL2; NIL-2-A zinc finger protein; posterior polymorphous corneal dystrophy 3; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); twirler; Zfhep; Zinc finger E-box-binding homeobox 1; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1a; Zinc finger homeobox protein 1b; Zinc finger homeodomain enhancer-binding protein

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基因别名: 3110032K11Rik; 9130203F04Rik; [delta]EF1; AREB6; BZP; D130016B08Rik; DELTAEF1; FECD6; HRIHFB2411; HSPC082; KIAA0569; MEB1; Nil2; NIL2A; PPCD3; SIP-1; SIP1; SMADIP1; TCF-8; Tcf18; TCF8; Tw; ZEB; ZEB1; ZEB2; ZFHEP; ZFHX1A; ZFHX1B; Zfx1a; ZFX1B; Zfx1ha; Zfxh1b

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UniProt ID: (Human) P37275, (Human) O60315, (Mouse) Q64318, (Rat) Q62947, (Mouse) Q9R0G7

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Entrez Gene ID: (Human) 6935, (Human) 9839, (Mouse) 21417, (Rat) 25705, (Mouse) 24136, (Rat) 311071

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功能
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding transcription factor binding zinc ion binding E-box binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding DNA binding phosphatase regulator activity metal ion binding R-SMAD binding nucleic acid binding double-stranded DNA binding sequence-specific DNA binding molecular_function C2H2 zinc finger transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription from RNA polymerase II promoter immune response pattern specification process central nervous system development cell proliferation negative regulation of cell proliferation regulation of mesenchymal cell proliferation regulation of transforming growth factor beta receptor signaling pathway negative regulation of epithelial cell differentiation regulation of T cell differentiation in thymus positive regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic camera-type eye morphogenesis embryonic skeletal system morphogenesis semicircular canal morphogenesis regulation of smooth muscle cell differentiation cartilage development cellular response to amino acid stimulus cochlea morphogenesis neural crest cell migration somitogenesis neural tube closure transcription from RNA polymerase II promoter nervous system development corpus callosum morphogenesis hippocampus development cell proliferation in forebrain corticospinal tract morphogenesis positive regulation of Wnt signaling pathway positive regulation of JUN kinase activity positive regulation of melanocyte differentiation positive regulation of melanin biosynthetic process developmental pigmentation collateral sprouting positive regulation of axonogenesis mammillary axonal complex development melanocyte migration positive regulation of lens fiber cell differentiation regulation of melanosome organization regulation of transcription, DNA-templated cell differentiation animal organ development embryonic morphogenesis response to activity forebrain development response to nutrient levels cellular response to transforming growth factor beta stimulus biological_process
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