Proteintech

ZFP36 Monoclonal Antibody (1A5E6)

4 篇参考文献
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说明书
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说明书
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问题与答案
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说明书
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问题与答案
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产品信息

66938-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:3,000
查看2篇已发表文章 2篇已发表文章

免疫细胞化学 (ICC/IF)

-
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免疫沉淀 (IP)

-
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产品规格

种属反应

Human, Mouse, Pig

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

1A5E6

抗原

ZFP36 Fusion Protein Ag28473

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1000 µg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Aliquoting is unnecessary for -20°C storage.

靶标信息

ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CCCH (CX8CX5CX3H) zinc finger domain RNA-binding protein; G0/G1 switch regulatory protein 24; Growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; TPA-induced sequence 11; Tristetraprolin; tristetraproline; Zfp-36; Zinc finger protein 36; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog; zinc finger protein, C3H type, 36 homolog

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基因别名: G0S24; GOS24; NUP475; RNF162A; TIS11; TIS11A; TIS11D; TISII; TTP; Zfp-36; ZFP36

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UniProt ID: (Human) P26651, (Mouse) P22893

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Entrez Gene ID: (Human) 7538, (Pig) 100316849, (Mouse) 22695

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功能
DNA binding single-stranded RNA binding mRNA binding mRNA 3'-UTR binding protein binding AU-rich element binding enzyme binding protein kinase binding C-C chemokine binding mRNA 3'-UTR AU-rich region binding poly(A) RNA binding metal ion binding 14-3-3 protein binding RNA metabolism protein
参与通路
negative regulation of transcription from RNA polymerase II promoter MAPK cascade nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening mRNA catabolic process response to wounding regulation of keratinocyte proliferation nuclear-transcribed mRNA catabolic process, deadenylation-independent decay regulation of tumor necrosis factor production miRNA mediated inhibition of translation p38MAPK cascade response to starvation regulation of mRNA stability cellular response to fibroblast growth factor stimulus positive regulation of fat cell differentiation regulation of keratinocyte differentiation negative regulation of erythrocyte differentiation mRNA transport positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of keratinocyte apoptotic process positive regulation of intracellular mRNA localization regulation of transcription from RNA polymerase II promoter intracellular signal transduction negative regulation of myeloid cell differentiation negative regulation of inflammatory response RNA destabilization
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