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Proteintech
ZFP36L2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
19005-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ZFP36L2 Fusion Protein Ag13518 (155-497 aa encoded by BC005010)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.15 mg/mL
规格
22.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: KTELCRPFE ESGTCKYGEK CQFAHGFHEL RSLTRHPKYK TELCRTFHTI GFCPYGPRCH FIHNADERRP APSGGASGDL RAFGTRDALH LGFPREPRPK LHHSLSFSGF PSGHHQPPGG LESPLLLDSP TSRTPPPPSC SSASSCSSSA SSCSSASAAS TPSGAPTCCA SAAAAAAAAL LYGTGGAEDL LAPGAPCAAC SSASCANNAF AFGPELSSLI TPLAIQTHNF AAVAAAAYYR SQQQQQQQQQ QGLAPPAQPP APPSATLPAG AAAPPSPPFS FQLPRRLSDS PVFDAPPSPP DSLSDRDSYL SGSLSSGSLS GSESPSLDPG RRLPIFSRLS ISDD (155-497 aa encoded by B C005010)
靶标信息
TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2 or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers. Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5'UUAUUUAUUU-3' core RNA sequences and may regulate growth factor-induced cellular responses. The gene encoding TIS11D maps to human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: butyrate response factor 2; butyrate response factor 2 (EGF-response factor 2); EGF-response factor 2; ERF-2; Protein TIS11D; TIS11d(del); TIS11d(ins); TISD; TPA-induced sequence 11d; unnamed protein product; ZFP36 ring finger protein like 2; ZFP36-like 2; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; zinc finger protein 36, C3H1 type-like 2; zinc finger protein 36, C3H1 type-like 2-like; zinc finger protein, C3H type, 36-like 2
基因别名: BRF2; ERF-2; ERF2; OOMD13; OZEMA13; RNF162C; TIS11D
UniProt ID: (Human) P47974, (Mouse) P23949
Entrez Gene ID: (Human) 678, (Mouse) 12193, (Rat) 298765
MAPK cascade
nuclear-transcribed mRNA poly(A) tail shortening
mRNA catabolic process
response to wounding
negative regulation of translation
hemopoiesis
T cell differentiation in thymus
somatic stem cell population maintenance
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
regulation of B cell differentiation
negative regulation of fat cell differentiation
somatic stem cell division
definitive hemopoiesis
3'-UTR-mediated mRNA destabilization
ERK1 and ERK2 cascade
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to glucocorticoid stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of mitotic cell cycle phase transition
negative regulation of stem cell differentiation
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of gene expression
positive regulation of mRNA catabolic process
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