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Abnova
ZFYVE21 Polyclonal Antibody, MaxPab™
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产品信息
H00079038-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ZFYVE21 (NP_076976, 1 a.a. approximately 234 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSSEVSARRD AKKLVRSPSG LRMVPEHRAF GSPFGLEEPQ WVPDKECRRC MQCDAKFDFL TRKHHCRRCG KCFCDRCCSQ KVPLRRMCFV DPVRQCAECA LVSLKEAEFY DKQLKVLLSG ATFLVTFGNS EKPETMTCRL SNNQRYLFLD GDSHYEIEIV HISTVQILTE GFPPGGGNAR ATGMFLQYTV PGTEGVTQLK LTVVEDVTVG RRQAVAWLVA MHKAAKLLYE SRDQ
靶标信息
ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FYVE domain containing 21; HCV p7-transactivated protein 1; ZF21; Zinc finger FYVE domain-containing protein 21; zinc finger, FYVE domain containing 21
基因别名: HCVP7TP1; ZF21; ZFYVE21
UniProt ID: (Human) Q9BQ24
Entrez Gene ID: (Human) 79038
