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Proteintech
ZGPAT Polyclonal Antibody
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产品信息
23203-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ZGPAT Fusion Protein Ag19620 (173-511 aa encoded by BC032612)
偶联物
形式
Liquid
浓度
0.24 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: THKSLKPCP FFLEGKCRFK ENCRFSHGQV VSLDELRPFQ DPDLSSLQAG SACLAKHQDG LWHAARITDV DNGYYTVKFD SLLLREAVVE GDGILPPLRT EATESDSDSD GTGDSSYARV VGSDAVDSGT CSSAFAGWEV HTRGIGSRLL TKMGYEFGKG LGRHAEGRVE PIHAVVLPRG KSLDQCVETL QKQTRVGKAG TNKPPRCRGR GARPGGRPAP RNVFDFLNEK LQGQAPGALE AGAAPAGRRS KDMYHASKSA KRALSLRLFQ TEEKIERTQR DIRSIQEALA RNAGRHSVAS AQLQEKLAGA QRQLGQLRAQ EAGLQQEQRK ADTHKKMTEF (173-511 aa encoded by BC032612)
靶标信息
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G patch domain-containing protein 6; Zinc finger and G patch domain-containing protein; Zinc finger CCCH domain-containing protein 9; zinc finger CCCH-type with G patch domain; Zinc finger CCCH-type with G patch domain-containing protein; zinc finger, CCCH-type with G patch domain; zinc finger, CCCH-type with G-patch domain
基因别名: 1500006I01Rik; BC021513; GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZGPAT; ZIP
UniProt ID: (Human) Q8N5A5, (Mouse) Q8VDM1
Entrez Gene ID: (Human) 84619, (Mouse) 229007
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
metal ion binding
nucleic acid binding
DNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of epidermal growth factor-activated receptor activity
negative regulation of transcription, DNA-templated
