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Invitrogen
ZNF366 Polyclonal Antibody
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FIGURE: 1 / 1
ZNF366 Antibody (PA5-47653) in Flow
Flow cytometry of ZNF366 in Human mature dentritic cells differentated from human peripheral blood mononuclear cell derived CD14+ cells treated with 20 ng/mL Recombinant Human IL‚4 and 50 ng/mL Recombinant Human GM‚CSF for 7 days and 1 μg/mL LPS, 20 ng/mL Recombinant Human TNF‚α , and 20 ng/mL Recombinant Human IL‚1β/IL‚1F2 for last 24 hours. Samples were incubated in ZNF366 polyclonal antibody (Product # PA5-47653) or control antibody followed by Donkey Anti-Goat IgG (H+L) Phycoerythrin. To facilitate intracellular staining, cells were fi... View More
Product Details
PA5-47653
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human DC-SCRIPT/ZNF366 Met559-Ile744
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) ZNF24 and rhZNF206 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Zinc finger protein 366 (ZNF366), also known as Zinc finger estrogen receptor binding domain-containing protein 1, is a gene located on chromosome 5q31.2 that encodes a transcription factor characterized by zinc finger domains. These domains are crucial for DNA binding, allowing ZNF366 to regulate gene expression by interacting with specific DNA sequences. ZNF366 is involved in modulating the activity of various signaling pathways, including those related to hormone receptors, such as the estrogen receptor, impacting cellular processes like development, differentiation, and proliferation. The protein's specific functional roles are still under investigation, but it is thought to contribute to transcriptional regulation and chromatin remodeling. Altered expression or mutations of ZNF366 have been associated with certain cancers, particularly breast cancer, where its regulatory functions may influence tumorigenesis. Research on ZNF366 continues to explore its potential role in disease mechanisms and therapeutic strategies, particularly in oncology and endocrine-related disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DC-SCRIPT; Dendritic cell-specific transcript protein; Zinc finger protein 366
Gene Aliases: DCSCRIPT; ZNF366
UniProt ID: (Human) Q8N895
Entrez Gene ID: (Human) 167465
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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