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ZNF496 Monoclonal Antibody (4B1)
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产品信息
H00084838-M02
产品规格
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4B1
抗原
ZNF496 (NP_116141, 485 a.a. approximately 585 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
See Label
规格
100 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: HLQPDRLQPV EKREQAASED ADKGPKEPLE NGKAKLSFQC CECGKAFQRH DHLARHRSHF HLKDKARPFQ CRYCVKSFTQ NYDLLRHERL HMKRRSKQAL N
靶标信息
ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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