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Invitrogen
Zyxin Recombinant Rabbit Monoclonal Antibody (4F9P3)
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产品信息
MA5-42774
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4F9P3
抗原
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Zyxin (Q15942).
偶联物
形式
Liquid
浓度
1.1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: MCF7, Mouse lung. The target is usually found in the following locations: Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion.
Immunogen sequence: TQPRGPPASS PAPAPKFSPV TPKFTPVASK FSPGAPGGSG SQPNQKLGHP EALSAGTGSP QPPSFTYAQQ REKPRVQEKQ HPVPPPAQNQ NQVRSPGAPG P
靶标信息
Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Zyxin; Zyxin-2
基因别名: 9530098H06Rik; ESP-2; HED-2; R75157; ZYX
UniProt ID: (Human) Q15942, (Mouse) Q62523
Entrez Gene ID: (Human) 7791, (Mouse) 22793
