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Invitrogen
alpha-2b Adrenergic Receptor (extracellular) Polyclonal Antibody
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alpha-2b Adrenergic Receptor (extracellular) Antibody (PA5-77287) in IHC (P)
Immunohistochemistry analysis of alpha-2b Adrenergic Receptor (extracellular) in paraffin-embedded rat lung. Samples were probed with alpha-2b Adrenergic Receptor (extracellular) polyclonal antibody (Product # PA5-77287) using a dilution of 1:100, and incubated with hematoxylin.
产品信息
PA5-77287
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide (C)RPEPRGLPQ*SELNQE, corresponding to amino acid residues 160-174 of rat alpha2B - Adrenoceptor with replacement of cysteine 169 (C169 ) with serine (*S)
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
靶标信息
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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