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Invitrogen
amyloid beta oligomers (Sabirnetug Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA562586
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG2, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Amyloid beta oligomers are aggregates of the amyloid beta peptide, which is derived from the amyloid precursor protein (APP) through enzymatic cleavage. These oligomers are considered to be neurotoxic and have been implicated in the pathogenesis of Alzheimer's disease. Structurally, these oligomers can vary in size and form, ranging from dimers to large aggregates, and their formation is influenced by factors such as the peptide concentration, pH, and presence of metals. Functionally, these oligomers disrupt cellular processes, leading to synaptic dysfunction, oxidative stress, and ultimately neuronal death. They exert their toxic effects by interacting with cell membranes, forming pores, and triggering intracellular signaling pathways that result in neurodegeneration. The exact mechanisms by which Amyloid beta oligomers contribute to Alzheimer's disease are still under investigation, but they are a key focus of therapeutic strategies aimed at mitigating the progression of the disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABPP; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; amyloid beta; Amyloid precursor protein; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; APP; APPI; Cerebral vascular amyloid peptide; CVAP; PN-II; PreA4; Protease nexin-II
基因别名: A4; AD1; APP
Entrez Gene ID: (Human) 351
Disclaimer
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