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PA1-25659 detects beta 2 Adrenergic Receptor from human samples.
PA1-25659 has been successfully used in Western blot procedures.
The PA1-25659 immunogen is a synthetic peptide corresponding to residues 335-408 of human beta 2 Adrenergic Receptor.
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。