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Invitrogen
c-MAF Recombinant Mouse Monoclonal Antibody (sym0F1)
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c-MAF Antibody (740099M) in Flow
Flow cytometry analysis of c-MAF Recombinant Mouse Monoclonal Antibody (sym0F1) (Product # 740099M) was performed using RPMI 8226 and Daudi cells. Cells were fixed with eBioscience™ Foxp3/Transcription Factor Staining Buffer Set (Product # 00-5523-00), permeabilized and stained with 0.0625 µg of the c-MAF Recombinant Mouse Monoclonal Antibody (sym0F1) (Product # 740099M), followed by Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor™ Plus 647 (Product # A55060, 1:1,000). Higher expression of c-MAF was observed in RPMI ... View More
产品信息
740099M
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
sym0F1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant mouse monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; c-maf proto-oncogene; MGC71685; Proto-oncogene c-Maf; T lymphocyte c-maf long form; Transcription factor Maf; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog
基因别名: AYGRP; c-MAF; CCA4; CTRCT21; MAF
UniProt ID: (Human) O75444
Entrez Gene ID: (Human) 4094
negative regulation of transcription from RNA polymerase II promoter
cytokine production
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of chondrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
inner ear development
lens fiber cell differentiation
