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Proteintech
c-MYC Polyclonal Antibody
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产品信息
10828-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
c-MYC Fusion Protein Ag1263 (16-454 aa encoded by BC000141)
偶联物
形式
Liquid
浓度
0.29 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC. The 50 kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70 kDa, are the phosphorylated form of MYC .
Immunogen sequence: MPLNVSFTN RNYDLDYDSV QPYFYCDEEE NFYQQQQQSE LQPPAPSEDI WKKFELLPTP PLSPSRRSGL CSPSYVAVTP FSLRGDNDGG GGSFSTADQL EMVTELLGGD MVNQSFICDP DDETFIKNII IQDCMWSGFS AAAKLVSEKL ASYQAARKDS GSPNPARGHS VCSTSSLYLQ DLSAAASECI DPSVVFPYPL NDSSSPKSCA SQDSSAFSPS SDSLLSSTES SPQGSPEPLV LHEETPPTTS SDSEEEQEDE EEIDVVSVEK RQAPGKRSES GSPSAGGHSK PPHSPLVLKR CHVSTHQHNY AAPPSTRKDY PAAKRVKLDS VRVLRQISNN RKCTSPRSSD TEENVKRRTH NVLERQRRNE LKRSFFALRD QIPELENNEK APKVVILKKA TAYILSVQAE EQKLISEEDL LRKRREQLKH KLEQLRNSCA (16-454 aa encoded by BC000141)
靶标信息
The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; c-myc epitope tag; c-myc proto-oncogene; Class E basic helix-loop-helix protein 39; cmyc; Myc protein; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; Proto-oncogene c-Myc; Transcription factor p64; v-myc myelocytomatosis viral oncogene homolog
基因别名: AU016757; BHLHE39; c-Myc; MRTL; MYC; Myc2; MYCC; Niard; Nird
UniProt ID: (Human) P01106, (Mouse) P01108
Entrez Gene ID: (Human) 4609, (Mouse) 17869
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein complex binding
protein dimerization activity
repressing transcription factor binding
E-box binding
core promoter proximal region sequence-specific DNA binding
double-stranded DNA binding
sequence-specific DNA binding
protein heterodimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
branching involved in ureteric bud morphogenesis
positive regulation of mesenchymal cell proliferation
energy reserve metabolic process
chromatin remodeling
transcription from RNA polymerase II promoter
cellular iron ion homeostasis
cellular response to DNA damage stimulus
cell cycle arrest
Notch signaling pathway
positive regulation of cell proliferation
response to gamma radiation
regulation of gene expression
oxygen transport
regulation of telomere maintenance
negative regulation of stress-activated MAPK cascade
cellular response to UV
cellular response to drug
response to drug
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
fibroblast apoptotic process
negative regulation of monocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
negative regulation of fibroblast proliferation
positive regulation of epithelial cell proliferation
chromosome organization
negative regulation of cell division
canonical Wnt signaling pathway
response to growth factor
positive regulation of metanephric cap mesenchymal cell proliferation
beta-catenin-TCF complex assembly
positive regulation of DNA biosynthetic process
positive regulation of response to DNA damage stimulus
B cell apoptotic process
regulation of oxidative phosphorylation
positive regulation of B cell apoptotic process
glucose metabolic process
transcription, DNA-templated
DNA-templated transcription, initiation
regulation of transcription, DNA-templated
pyruvate transport
amino acid transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
inner mitochondrial membrane organization
regulation of mitotic cell cycle
cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
response to radiation
negative regulation of gene expression
positive regulation of mitochondrial membrane potential
Wnt signaling pathway
protein processing
transformation of host cell by virus
negative regulation of protein binding
skeletal muscle cell differentiation
middle ear morphogenesis
regulation of apoptotic process
positive regulation of catalytic activity
response to alkaloid
pigmentation
canonical Wnt signaling pathway involved in positive regulation of wound healing
canonical Wnt signaling pathway involved in negative regulation of apoptotic process
canonical Wnt signaling pathway involved in positive regulation of apoptotic process
positive regulation of cell cycle
positive regulation of glycolytic process
negative regulation of glucose import
lactic acid secretion
skeletal system morphogenesis
detection of mechanical stimulus involved in sensory perception of sound
negative regulation of cell death
positive regulation of cellular respiration
positive regulation of ATP biosynthetic process
positive regulation of apoptotic signaling pathway
