Invitrogen

c-Met Recombinant Rabbit Monoclonal Antibody (6O7V1)

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说明书
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问题与答案
技术支持
说明书
实验方案
问题与答案
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说明书
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c-Met Recombinant Rabbit Monoclonal Antibody (6O7V1)

产品信息

MA5-57868

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

6O7V1

抗原

Recombinant protein (or fragment)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Dry ice (international)

RRID

AB_3680892

产品详细信息

Immunogen sequence: QIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG SCRQVQYPLT DMSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH FNEVIGRGHF GCVYHGTLLD NDGKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK FT

靶标信息

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF receptor; HGF-SF receptor; HGF/SF receptor; met proto-oncogene tyrosine kinase; oncogene MET; Proto-oncogene c-Met; sc MET; Scatter factor receptor; SF receptor; soluble c met; Tyrosine-protein kinase Met

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基因别名: AI838057; AUTS9; c-Met; DFNB97; HGF; HGFR; MET; Par4; RCCP2

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UniProt ID: (Human) P08581

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Entrez Gene ID: (Human) 4233, (Mouse) 17295

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功能
protein tyrosine kinase activity hepatocyte growth factor-activated receptor activity protein binding ATP binding protein phosphatase binding nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity beta-catenin binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein complex binding phospholipase binding phosphatidylinositol 3-kinase binding protein heterodimerization activity transmembrane signal receptor
参与通路
endothelial cell morphogenesis signal transduction cell surface receptor signaling pathway cell proliferation negative regulation of autophagy peptidyl-tyrosine phosphorylation positive regulation of transcription from RNA polymerase II promoter hepatocyte growth factor receptor signaling pathway branching morphogenesis of an epithelial tube positive chemotaxis semaphorin-plexin signaling pathway negative regulation of hydrogen peroxide-mediated programmed cell death positive regulation of endothelial cell chemotaxis negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity neuron migration liver development placenta development protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway brain development muscle organ development skeletal muscle tissue development positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation positive regulation of glucose transport positive regulation of neuron projection development muscle cell migration myotube differentiation phosphorylation sperm motility adult behavior positive regulation of peptidyl-serine phosphorylation glucose homeostasis positive regulation of DNA replication positive regulation of mitotic nuclear division protein autophosphorylation positive regulation of dendrite morphogenesis modulation of synaptic transmission myoblast proliferation excitatory postsynaptic potential regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
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