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Invitrogen
eIF3c Polyclonal Antibody
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eIF3c Antibody (PA1-31377) in WB
Western blot analysis of EIF3S8 using A) Whole cell lysate (15 or 50µg) from C2C12 (mouse) and L6 (rat) cells and B) Whole cell lysate (12.5µg for Input and 1 mg for IP) from HEK293 cells. Samples were probed with an EIF3S8 polyclonal antibody (Product # PA1-31377) at a dilution of 0.04µg/ml for WB (A and B) and 5µg/mg lysate for IP (B). Detection was performed using chemiluminescence with exposure times of 2-4 minutes.
产品信息
PA1-31377
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR , corresponding to N terminal amino acids 1-50 of Human Eif3s8.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
PA1-31377 detects EIF3S8 from human samples.
PA1-31377 has been successfully used in immunoprecipitation, Western blot applications.
The PA1-31377 immunogen is: Synthetic peptide: MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR , corresponding to N terminal amino acids 1-50 of Human Eif3s8.
靶标信息
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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