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Invitrogen
p14ARF Polyclonal Antibody
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产品信息
PA1-28218
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptidecorresponding to the Human C terminal region.
偶联物
形式
Liquid
保存条件
4°C, do not freeze
运输条件
Wet ice
RRID
产品详细信息
PA1-28218 detects p14ARF from human samples.
PA1-28218 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-28218 immunogen is: Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (C terminal).
靶标信息
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein, ARF (p14ARF in human and P19ARF in mouse). These two proteins interact with the upstream proteins: retinoblastoma protein and p53 tumor suppressors, respectively. Each of these proteins has a role in the senescence of primary cells, activates pathways for cell cycle control and tumor suppression. The p14ARF (or P19ARF in mouse) proteins can induce both G1 and G2 phase arrest in a manner that depends on functional p53. The mouse and human ARF proteins have different functions in tumor suppression; this distinction may contribute to the different levels of tumor proneness of these species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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