Invitrogen

p53 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (HL2697)

Name: p53 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (HL2697)
Brand: Invitrogen
SKU: MA568111

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说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

p53 (Tumor Suppressor Protein) Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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p53 (Tumor Suppressor Protein) Antibody (MA568111) in IHC (PFA)

Immunohistochemistry analysis of p53 (Tumor Suppressor Protein) in paraformaldehyde-fixed 1 day-post-fertilization zebrafish embryo. Samples were incubated with p53 (Tumor Suppressor Protein) recombinant monoclonal antibody (Product # MA568111) using a dilution of 1:100. Antigen Retrieval: Tris-HCl buffer, pH 90, 20 min at 70°C.

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产品信息

MA568111

应用

建议稀释比

已发表文章

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:100

产品规格

种属反应

Zebrafish

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

HL2697

抗原

Recombinant fragment of zebrafish p53.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cellular tumor antigen p53; Cys 51 Stop; delta113 p53; FLJ92943; HGNC11998; OTTMUSP00000006194; p53beta isoform; Tumor suppressor p53; Tumour Protein p53

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基因别名: brp53; drp53; etID22686.5; fb40d06; p53; tp53; wu:fb40d06; zgc:111919

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UniProt ID: (Zebrafish) P79734

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Entrez Gene ID: (Zebrafish) 30590

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功能

DNA binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding metal ion binding promoter-specific chromatin binding P53-like transcription factor

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