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Invitrogen
pro-CRF Polyclonal Antibody
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产品信息
PA5-149074
产品规格
种属反应
Human
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human Pro-Corticoliberin/Pro-CRH, Leu25-Lys196
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Pro-CRF, or pro-corticotropin-releasing factor, is the precursor form of corticotropin-releasing factor (CRF), a crucial peptide hormone involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. The CRF gene encodes this precursor, which undergoes proteolytic processing to produce the mature CRF hormone. CRF plays a vital role in the body's response to stress by stimulating the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary gland. ACTH subsequently promotes the secretion of cortisol from the adrenal cortex, which helps to manage stress and maintain homeostasis. Beyond its role in the stress response, CRF is also involved in various other physiological processes, including immune function, digestion, and energy balance. Dysregulation of CRF expression or signaling can lead to a range of disorders, such as depression, anxiety, and stress-related conditions, as well as metabolic and inflammatory diseases. Understanding the regulation, processing, and function of pro-CRF is essential for developing therapeutic strategies aimed at treating these conditions. Research into pro-CRF provides insights into the broader mechanisms of stress regulation and its impact on health and disease, highlighting its potential as a target for pharmacological intervention.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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