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Invitrogen
pro-GDF1 Polyclonal Antibody
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产品信息
PA5-148664
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse GDF-1 Propeptide, Pro25-Leu235
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Pro-GDF1, or pro-growth differentiation factor 1, is the precursor form of GDF1, a protein that belongs to the transforming growth factor-beta (TGF-beta) superfamily. GDF1 is involved in various developmental processes, particularly in embryogenesis and the development of the central nervous system and cardiovascular system. During its synthesis, pro-GDF1 undergoes proteolytic processing to become the mature, active form. GDF1 plays a crucial role in the formation of the left-right axis during embryonic development, which is essential for the proper positioning and orientation of internal organs. It is also implicated in the regulation of cell differentiation and growth. Mutations or dysregulation in the GDF1 gene can lead to congenital heart defects, heterotaxy (a condition where the internal organs are abnormally arranged), and other developmental anomalies. Understanding the function and regulation of pro-GDF1 and its mature form is important for elucidating the molecular mechanisms underlying normal development and congenital disorders. Research into pro-GDF1 provides insights into the broader roles of TGF-beta family proteins in growth and differentiation, with potential implications for therapeutic strategies aimed at correcting developmental defects and promoting tissue regeneration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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