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This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; prepro-protein C; protein C (inactivator of coagulation factors Va and VIIIa); type I protein C; Vitamin K-dependent protein C
基因别名: APC; PC; PROC; PROC1; THPH3; THPH4
UniProt ID: (Human) P04070, (Rat) P31394
Entrez Gene ID: (Human) 5624, (Rat) 25268