Proteintech

uPA Polyclonal Antibody

40 篇参考文献
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说明书
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问题与答案
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说明书
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uPA Polyclonal Antibody

产品信息

17968-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
查看27篇已发表文章 27篇已发表文章

免疫组化 (IHC)

-
查看8篇已发表文章 8篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
-

免疫细胞化学 (ICC/IF)

1:20-1:200
查看3篇已发表文章 3篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg
查看1篇已发表文章 1篇已发表文章

不适用 (N/A)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

uPA Fusion Protein Ag11813 (82-431 aa encoded by BC013575)
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.29 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: ASTDTMGRP CLPWNSATVL QQTYHAHRSD ALQLGLGKHN YCRNPDNRRR PWCYVQVGLK PLVQECMVHD CADGKKPSSP PEELKFQCGQ KTLRPRFKII GGEFTTIENQ PWFAAIYRRH RGGSVTYVCG GSLISPCWVI SATHCFIDYP KKEDYIVYLG RSRLNSNTQG EMKFEVENLI LHKDYSADTL AHHNDIALLK IRSKEGRCAQ PSRTIQTICL PSMYNDPQFG TSCEITGFGK ENSTDYLYPE QLKMTVVKLI SHRECQQPHY YGSEVTTKML CAADPQWKTD SCQGDSGGPL VCSLQGRMTL TGIVSWGRGC ALKDKPGVYT RVSHFLPWIR SHTKEENGLA L (82-431 aa encoded by BC013575)

靶标信息

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: antagonist of uPA; CD87; HGNC:9052; plasminogen activator; plasminogen activator, urinary; U-plasminogen activator; uPA; UPAR; Urinary plasminogen activator, urokinase; URKR; Urokinase-type plasminogen activator

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基因别名: ATF; BDPLT5; PLAU; QPD; u-PA; UPA; UPAM; URK

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UniProt ID: (Human) P00749, (Mouse) P06869

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Entrez Gene ID: (Human) 5328, (Rat) 25619, (Mouse) 18792

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