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Human Flt-3 quantitates human Flt-3 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Flt-3.
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : CD135, FLK-2, FLK2, STK1
基因ID : (Human) 2322
基因符号 : FLT3
蛋白别名 : CD135 antigen, fetal liver kinase 2, FL cytokine receptor, fms related tyrosine kinase 3, fms-like tyrosine kinase 3, growth factor receptor tyrosine kinase type III, OTTHUMP00000214829, RP11-153M24.3, stem cell tyrosine kinase 1
UniProt ID (Human) P36888