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Human IGF2 ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of human IGF-2 in serum, plasma, and cell culture supernatants.
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : C11orf43, GRDF, IGF-II, PP9974, SRS3
基因ID : (Human) 3481
基因符号 : IGF2
蛋白别名 : FLJ22066, FLJ44734, H-IGF-2, IGF, Insulin like growth factor, GIG44, insulin-like growth factor 2 (somatomedin A), insulin-like growth factor II precursor, insulin-like growth factor type 2, insulin-like growth factor-II, preproinsulin-like growth factor II, domains A-E, preptin, somatomedin A, T3M-11-derived growth factor, unnamed protein product
UniProt ID (Human) P01344