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Human IL-21 R quantitates human IL-21 R in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IL-21 R.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : CD360, IMD56, NILR
基因ID : (Human) 50615
基因符号 : IL21R
蛋白别名 : class I cytokine receptor, IL-21 receptor, MGC10967, novel interleukin receptor, type I cytokine receptor, unnamed protein product
UniProt ID (Human) Q9HBE5