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Invitrogen
Human ISG15 ELISA Kit
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产品规格
检测灵敏度
1.64 ng/mL
测定范围
1.64-500 ng/mL
检测样本类型/体积
{Supernatant=100 µL, Plasma=100 µL, Serum=100 µL}
手工操作时间
1 hr 20 min
总时间
4 hr 45 min
均相（无需洗涤）
No
批间差异
12%
批内差异
10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated microwell plate
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Sample Diluent
Wash Buffer Concentrate
Assay Buffer concentrate
Stop Solution
Substrate Solution
Adhesive Plate Covers
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Sample Diluent
Wash Buffer Concentrate
Assay Buffer concentrate
Stop Solution
Substrate Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
-20°C
蛋白名称
ISG15
均相（无需洗涤）
Human
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
Human ISG15 ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of human ISG15 in serum, plasma, and cell culture supernatants.
靶标信息
Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. It is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MCH (major histocompatibility complex)-restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega, but not IFN-gamma. ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog. Mutations affecting the gene can result in Immunodeficiency 38, with basal ganglia calcification (IMD38).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : G1P2, hUCRP, IFI15, IMD38, IP17, ISG15, UCRP
基因ID : (Human) 9636
基因符号 : ISG15
蛋白别名 : hUCRP, interferon, alpha-inducible protein (clone IFI-15K), Interferon-induced 15 kDa protein, Interferon-induced 17 kDa protein, interferon-induced 17-kDa/15-kDa protein, interferon-stimulated protein, 15 kDa, IP17, Ubiquitin cross-reactive protein, Ubiquitin-like protein ISG15
UniProt ID (Human) Q5SVA4
