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Invitrogen
Human Presenilin 1 ELISA Kit
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产品规格
检测灵敏度
10.5 pg/mL
测定范围
10.5-2,500 pg/mL
检测样本类型/体积
{Supernatant=50 µL, Serum=50 µL, Plasma=50 µL}
手工操作时间
1 hr 20 min
总时间
4 hr 45 min
均相（无需洗涤）
No
批间差异
<12%
批内差异
<10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated 96 well plate
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
蛋白名称
Presenilin 1
均相（无需洗涤）
Human
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
Human Presenilin 1 quantitates human Presenilin 1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Presenilin 1.
靶标信息
Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : AD3, FAD, PS-1, PS1, PSEN1, PSNL1, S182
基因ID : (Human) 5663
基因符号 : PSEN1
蛋白别名 : Alzheimer Disease 3, Minilin, presenilin1, S182 protein, Senilin 1, Presenilin-1, Protein S182, PS-1
UniProt ID (Human) P49768
