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Monkey BLC quantitates monkey BLC in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant monkey BLC.
CXCL13, also known as BCA-1 and Angie, is a small chemokine strongly expressed in the secondary lymphoid organs. It preferentially promotes the migration of B lymphocytes (both B-1 and B-2) to the follicles of the spleen, lymph nodes, and Peyer's patches. It is produced by macrophages, and in mouse the highest constitutive producers include large peritoneal macrophages, Kuppfer cells and lung macrophages (both CD11c+ and CD11c-). The cellular ligand for CXCL13 is CXCR5 also known as BLR-1 (Burkitt's Lymphoma Receptor 1). CXCR5 is expressed on B cells, Tfh cells and, to a lower degree, some memory T cell populations. CXCL13 plays an important role in the development of chronic lymphocytic leukemia (CCL). CXCL13 is also a plasma biomarker for germinal center activity and generation of broadly neutralizing antibodies against HIV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13
基因ID : (Human) 10563
基因符号 : CXCL13
蛋白别名 : b cell-attracting chemokine 1, b lymphocyte chemoattractant, B-cell chemoattractant, B-cell-attracting chemokine 1, B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1), B-lymphocyte chemoattractant, chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant), cxc chemokine, CXC chemokine BLC, CXC, CXC motif chemokine, CXC motif chemokine 13, CXCL, C Cmotif chemokine, C X C motif chemokine, CC motif chemokine, CCmotif chemokine, chem, CXCL13, small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant), small-inducible cytokine B13
UniProt ID (Human) O43927