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Human Semaphorin 6D quantitates human Semaphorin 6D in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Semaphorin 6D.
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphoring domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. SEMA6D is a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因ID : (Human) 80031
基因符号 : SEMA6D
蛋白别名 : axon guidance family member, FLJ11598, KIAA1479FLJ11598, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, unnamed protein product
UniProt ID (Human) Q8NFY4