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The Human TACI (TNFRSF13B) ELISA quantitates Hu TACI in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu TACI.
原理方法
The Human solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.
严格验证
Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.
Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF13B, TNFRSF14B
基因ID : (Human) 23495
基因符号 : TNFRSF13B
蛋白别名 : CD267, Transmembrane activator and CAML interactor, tumor necrosis factor receptor 13B, Tumor necrosis factor receptor superfamily member 13B, tumor necrosis factor receptor superfamily, member 13B
UniProt ID (Human) O14836