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Human TEK ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of human Tie-2 in cell culture supernatants, plasma, and serum samples.
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1
基因ID : (Human) 7010
基因符号 : TEK
蛋白别名 : CD202b antigen, EC 2.7.10, EC 2.7.10.1, TEKT1, Tektin-1, endothelial tyrosine kinase, TEK tyrosine kinase, endothelial, tunica interna endothelial cell kinase, tyrosine kinase with Ig and EGF homology domains-2, tyrosine-protein kinase receptor TEK, tyrosine-protein kinase receptor TIE-2, unnamed protein product
UniProt ID (Human) Q02763