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Human Trypsin 2/PRSS2 quantitates human Trypsin 2/PRSS2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Trypsin 2/PRSS2.
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : TRY2, TRY8, TRYP2
基因ID : (Human) 5645
基因符号 : PRSS2
蛋白别名 : anionic trypsinogen, EC 3.4.21, EC 3.4.21.4, MGC111183, MGC120174, MGC120175, trypsin Trypsin II, protease serine 2 preproprotein, protease, serine 2, serine, 2 (trypsin 2), trypsin II, trypsinogen 2
UniProt ID (Human) P07478