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Invitrogen
Mouse CD223 (LAG-3) ELISA Kit
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产品规格
检测灵敏度
2.53 ng/mL
测定范围
2.53-800 ng/mL
检测样本类型/体积
{Serum=100 µL, Supernatant=100 µL, Plasma=100 µL}
手工操作时间
1 hr 20 min
总时间
4 hr 45 min
均相（无需洗涤）
No
批间差异
12%
批内差异
10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated microwell plate
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Sample Diluent
Wash Buffer Concentrate
Assay Buffer concentrate
Stop Solution
Substrate Solution
Adhesive Plate Covers
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Sample Diluent
Wash Buffer Concentrate
Assay Buffer concentrate
Stop Solution
Substrate Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
-20°C
蛋白名称
LAG-3 (CD223)
均相（无需洗涤）
Mouse
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
Mouse CD223 (LAG-3) ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of mouse LAG-3 in cell culture supernatants, plasma, and serum samples.
靶标信息
LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : CD223, LAG-3, Lag3, Ly66
基因ID : (Mouse) 16768
基因符号 : Lag3
蛋白别名 : Activation-induced cytidine deaminase-linked autoimmunity protein, Aida, CD223, LAG-3, Lymphocyte activation gene 3 protein, sLAG 3, sLAG3, soluble LAG 3lymphocyte activating 3, soluble LAG3
UniProt ID (Mouse) Q61790
