Cryo-electron microscopy (cryo-EM) is transforming biologics, small molecule drug discovery, and the development of next-generation delivery vehicles for vaccines and gene therapy. Scientists in companies of all sizes are now able to leverage direct imaging and advanced analytics to:

  • Expand the use of structural biology to dynamic, flexible systems and study heterogeneous complexes
  • Determine mechanisms of action for drug candidates, discover cryptic binding sites, and better understand allosteric regulation
  • Support engineering of novel gene editors with reproducible, high-throughput structure determination
  • Rapidly map epitopes at high resolution, even multiplexing for non-competitive monoclonal antibodies
  • Determine multiple critical quality attributes from single imaging sessions for lipid nanoparticles, viral vectors, and novel subunit vaccines

Join our event to learn more about cryo-EM and how it can benefit your research.

Event details

Time
12 p.m. – 1:30 p.m. EDT | Presentation and Q&A Session

Location
 Pennsylvania Biotechnology Center (PABC), Room 3100
3805 Old Easton Rd, Doylestown PA, 18902
Map

Speaker
Zuben Brown

Zuben Brown, Ph.D.
Senior Product Specialist, Electron Microscopy, Thermo Fisher Scientific

Dr. Brown obtained his undergraduate degree from the University of Sydney, Australia, and his PhD in structural biology from Osaka University, Japan. His postdoctoral work was completed at Columbia University in the lab of Nobel Prize winner Joachim Frank and used cryo-EM to study the structure of the Hepatitis C virus Internal Ribosome Entry Site as it hijacks the canonical cellular translation machinery. He has experience with all aspects of a cryo-EM project including operation of high-end microscopes, data collection strategies, computational analysis, and model building. He recently joined Thermo Fisher Scientific as a Senior Product Specialist.

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