Fill-Finish Solution

Fill-finish solutions are used to formulate and deliver sterile drug products like a biologics or vaccines aseptically into vials or prefilled syringes. They consist of bioprocessing containers or bags, surge bags, tubing, and filling needles, and a beta bag. The beta bag delivers the filling assembly into the isolator.

Fill-finish solutions include compounding, filtration, and filling assemblies all designed to maintain an aseptic environment. Compounding takes dry or concentrated API and mixes it with other components to create a stable formulation. To reduce the risk of microbial or residual contamination, filtration may be used as the next step in the fill-finish process, where filling assemblies—including the drug surge bag, tubing assemblies, and filling needles—are delivered into a filling isolator through a beta bag.

Aseptic filling is the process of transferring sterile products into sterile containers in a controlled environment to prevent contamination. The process includes sterilizing the product, containers, and equipment, followed by filling and sealing the containers using specialized machinery within an aseptic environment, often maintained by isolators or RABS. Single-use fill solutions like bags reduce risk of contamination and speed equipment turnover.

We have a large network of global manufacturing facilities that ensure redundancy in manufacturing and faster delivery times. Many of our fill-finish products are made-to-order using our Global Standard Component Library (GSCL), which includes pre-qualified components with standard claims. The GSCL features our most widely used components, selected for their broad applicability and universal relevance, and stocked within our network for efficient production and delivery.