HUPO 2025 World Congress

Unveiling the human molecular landscape: Integrated Omics in Translational research
Sunday, November 9, 2025 | 10:15 - 11:45 a.m.

Moderators:

• Khatereh Motamedchaboki, Sr Manager, Business Development, Thermo Fisher Scientific
• Yue Xuan, Sr Business Development Manager, Thermo Fisher Scientific

• Sample Preparation for Protein MS Analysis
• AccelerOme Automated Sample Preparation Platform
• Tandem Mass Tag (TMT) Systems
• Orbitrap Astral Mass Spectrometers
• Orbitrap Ascend Tribrid Mass Spectrometers
• Orbitrap Excedion Pro Mass Spectrometer
• Stellar Mass Spectrometer
• Single-Cell Proteomics
• Immunopeptidomics
• Quantitative Proteomics Mass Spectrometry
• Ardia Platform
• Proteome Discoverer Software
• Unity Lab Services

Poster session 1
Monday, November 10, 2025 | 1:15 - 3:15 p.m.

• Unlocking Precision Oncology: Harnessing Proteogenomics for Unmatched Insights from Big Data
• PTM Analysis with EThcD on a Modified Orbitrap Exploris Instrument
• nDIA analysis on the Orbitrap Astral combined with PTMScan enrichment provides an expanded global view of protein post translational modifications
• High Select Fe-NTA Magnetic Beads for Phosphopeptide Enrichment
• Discovering biomarkers in plasma through a highly multiplexed targeted proteomics assay utilizing the Stellar mass spectrometer and adaptive RT
• A Hybrid-DIA Approach for Simultaneous Targeted and Untargeted Analysis Using an Orbitrap Tribrid System
• Comprehensive and High-Throughput Plasma Proteome Profiling for Biomarker Discovery using a modified Orbitrap Astral Mass Spectrometer
• High-Throughput Plasma Proteomics Reveals Biological Insights Using PreOmics Sample Preparation Kits with the Thermo Scientific Orbitrap Astral Mass Spectrometer
• Scalable Plasma Proteomics Workflow Reveals Disease Insights Using the Seer Proteograph Workflow and the Thermo Scientific Orbitrap Astral Mass Spectrometer
• Leveraging Hybrid-DIA data acquisition modalities for comprehensive plasma proteomics analysis on modified Orbitrap Hybrid and modified Orbitrap Astral Mass Spectrometers
• Improved reproducibility and robustness for plasma proteomics on Orbitrap Astral MS using a novel automated ion source and separation cartridge
• Improved precision and accuracy in quantitative proteomics using a novel ion source on a modified Orbitrap Hybrid mass spectrometer
• Improved accuracy and identification in label-free quantitative proteomics using a novel ion source and separation cartridge with integrated replaceable emitters
• Enhancing the resolving power on a modified Orbitrap Astral mass spectrometer for TMT35plex applications
• Enhancing Glycopeptide Identification: Comparative Analysis of Orbitrap Mass Spectrometers
• Improved Quantitation in Proteomics Analysis Using Stellar Mass Spectrometry for High-Throughput Studies
• Enhancing Glycopeptide Identification: Comparative Analysis of Orbitrap Mass Spectrometers
• Leveraging Adaptive RT on Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer for Improved Sensitivity and Throughput in Targeted and Hybrid Workflows

Poster session 2
Tuesday, November 11, 2025 | 1:15 - 3:15 p.m.

• High-Throughput Molecular Glue Screening via Native Mass Spectrometry and Cryo-EM Analysis
• The Secret Life of Proteins and Drugs Through the Lens of Proteome Thermal Stability
• Evaluation of a novel, automated ion source for label-free peptide quantitation and global proteomics analysis
• Evaluation of OptiSpray Technology and the Orbitrap Astral Zoom Mass Spectrometer for Proteomics Applications
• Evaluation of prioritized peptide acquisition for multiplexed single-cell proteomics on an Orbitrap Astral Zoom mass spectrometer
• A novel tandem LC workflow for maximizing mass spectrometer utilization
• Low-input and single-cell proteomics sample analysis with a novel ion source and cartridge column on a Tribrid Mass Spectrometer
• Alternative fragmentation is not enough for Top-down MS and intact proteoform characterization
• Expanding the Landscape of Biomarker Discovery in a Multi-cancer Cohort

Poster session 3
Wednesday, November 12, 2025 | 1:15 - 3:15 p.m.

• Cutting-Edge Targeted Pathway Analysis: Advancing Functional Proteogenomics in Cancer Cells
• MS-cleavable Cross-linking analysis on modified Orbitrap Astral mass spectrometer
• Innovative data-independent acquisition (DIA) workflows for protein–nucleic acid interactions in living cells
• Enhanced immunopeptidome characterization with the high-sensitivity and accuracy of the modified Orbitrap Astral Mass Spectrometer
• Data-Independent acquisition for comprehensive immunopeptidome profiling on a modified Orbitrap Astral mass spectrometer
• Multiple target monitoring enables high throughput, large scale targeted assays for biomarker discovery and verification
• Expert Review - PRM Conductor - processing large-scale Stellar data
• Synchronous Precursor Selection of Light/Heavy Peptides on the MS-Level using the Stellar Mass Spectrometer
• Comprehensive Immunopeptidome Profiling with Optimized Enrichment and MS Analysis
• Capture Scheduled Retention Time Window Shift in Large Scale of Peptide Quantitation Using a Modified OrbitrapTM Hybrid Mass Spectrometer
• Hybrid-DIA on the modified Orbitrap Exploris 480 Mass Spectrometer: Bridging Global Depth and Targeted Sensitivity for Proteomic Analysis
• Higher Order Structure Characterization of ADCs using Hydrogen-deuterium Exchange Mass Spectrometry (HDX-MS)
• High-Throughput Protein Profiling of FFPE and Fresh-Frozen Samples Using BeatBox and Vanquish Neo Coupled with Orbitrap Astral

Corporate poster

• AAV6 VP3-Only Capsids for Standardization in Ion-Exchange Chromatography, Native Mass Spectrometry, and Charge Detection Mass Spectrometry
• Evaluation of Robustness and Reproducibility of the OptiSpray Ion Source and Cartridge Columns
• Evaluation Of the OptiSpray Ion Source And Cartridges With Integrated Replaceable Emitters For Proteomics Data Acquisition
• Experimental Characterization of Automated Emitter Position Optimization Strategies for a New Low-Flow Ion Source and Cartridge

Oral presentation
Wednesday, November 12, 2025 | 10:20 - 11:50 a.m.

• Experimental Characterization of Automated Emitter Position Optimization Strategies for a New Low-Flow Ion Source and Cartridge