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Immunopeptidomics Products

End-to-end solution for your immunopeptidomics research

Every part of our workflow has been optimized to generate maximum insight, removing the guesswork out of choosing the appropriate configuration for your experiments. We offer a complete solution plus a full range of resources to assist you throughout the entire workflow.

Sample preparation for immunopeptidomics

Sample preparation can be automated to increase throughput, decrease preparation time and technical variability.

KingFisher Flex Purification System

Prepare samples efficiently from a variety of materials with the Thermo Scientific KingFisher Flex Purification System, which offers highly versatile, automated magnetic-particle processing for DNA/RNA, protein, or cell purification from virtually any source. Using revolutionary magnetic particle separation technology, this system provides excellent reproducibility and quality.

Separations optimized for immunopeptidomics

Peptide separation columns must be robust, increase sensitivity, and provide retention time stability for immunopeptidomics experiments. uPAC Neo HPLC columns provide all of this as well as handle samples from high to limited amounts (single cell) and long to short gradients.

Vanquish Neo UHPLC System for experiments that require high reproducibility and sensitivity with low carryover

 

The Thermo Scientific Vanquish Neo UHPLC System enables high-sensitivity LC-MS applications such as immunopeptidomics. It flawlessly integrates with the industry-leading Thermo Scientific mass spectrometry portfolio and ESI sources.

50 cm µPAC Neo HPLC column for experiments that require highly reproducible separations

Thermo Scientific 50 cm µPAC Neo HPLC columns provide maximum proteome coverage from low to high cell count extractions for MHC samples. The unique micropillar array-based technology eliminates peak dispersion, creating higher plate counts and sharper peaks.

FAIMS Pro Duo interface - For experiments that require extended dynamic range

The Thermo Scientific FAIMS Pro Duo interface provides enhanced selectivity and sensitivity down to low picogram loading levels, allowing for deeper immunopeptidome coverage to observe differences in low abundant clinically relevant antigens. High-field asymmetric ion mobility technology allows ion cloud selectivity to target charge state ion clouds of MHC Class I and Class II peptides, while simultaneously keeping the mass spectrometer clean and the spectra pure.

Mass spectrometers for immunopeptidomics

The Thermo Scientific Orbitrap family of mass spectrometers offer reliable proven technology to support immunopeptidomics analysis with accuracy and precision.

 

Differentiating features of all Orbitrap instruments

  • Automatic gain control to enable consistent spectral quality and quantitative accuracy from picogram to microgram loading levels without user intervention
  • Normalized collision energy to enable reproducible fragmentation efficiency of all precursors without optimization within and across sample cohorts
  • Complete mass range (m/z) of MS/MS scans to enable unambiguous sequence annotation, particularly for de novo sequencing
  • Unparalleled spectral quality and intra-spectrum dynamic range enabled by the Orbitrap mass analyzer

Orbitrap Astral Mass Spectrometers - For experiments that require unprecedented depth

The Thermo Scientific Orbitrap Astral Mass Spectrometers offers a new level of depth in characterization of the immunopeptidome, with industry leading sensitivity of analysis, while maintaining the ability to analyze samples of high dynamic range. The platform supports samples of low amount (<pg) and high amount (>ug) without compromise or saturation of analysis.

Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer - Scale up your immunopeptidomics research

Using a revolutionary new hardware design, the Thermo Scientific Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer features two ion routing multipoles and multiple orthogonal fragmentation options for worldclass results in proteomics, metabolomics, lipidomics, glycoproteomics, and glycomics. It offers unique SQUAD workflows for simultaneous discovery and validation of immunopeptides across sample cohorts.

Orbitrap Excedion Pro Mass Spectrometer for experiments that require orbitrap accuracy and enhanced selectivity for targeted quantitation

The Thermo Scientific Orbitrap Exploris 480 Mass Spectrometer offers proven reliability and spectral quality to support accurate annotation of immunopeptides. The platform offers versatile operation to support data-dependent acquisition for discovery and unmatched selectivity for targeted quantitation with high resolution accurate mass PRM.

Stellar Mass Spectrometer - Discovery to validation at unprecedented scale

With 10X sensitivity improvements for 5X more analytes, the Thermo Scientific Stellar Mass Spectrometer accelerates biomarker translation more efficiently, confidently, and at a lower cost. Enhance certainty with the specificity of fast full-scan MSn acquisition and robust quantitation. Streamline high-throughput generation of high-quality data with automated method creation and instrument control.

Data analysis for Immunopeptidomics

PEAKS Studio software for data analysis

The PEAKS Studio software, with its DeepNovo Peptidome workflow, allows for the analysis of immunopeptide data obtained from Thermo Scientific Orbitrap mass spectrometers. This software provides functionality for database search and de novo peptide identification, enabling researchers to effectively analyze and interpret their data.

Our general purpose product lines, including LC-MS products, are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.

 

Our general purpose product lines have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in health and safety risks. They are designated for Research Use Only Applications.

 

For Research Use Only - Not For Use In Diagnostic Procedures.

The Thermo Scientific Orbitrap Exploris and Excedion series mass spectrometers are Orbitrap instruments with an atmospheric pressure ionization (API) source for liquid chromatography (LC) mass spectrometry (MS) high-throughput applications. The instruments are designed to be placed on a bench in the laboratory and maintain mass accuracy across chromatographic peaks, supporting confident identification and quantitation using high-resolution accurate-mass detection.