磷酰胺学习资源-赛默飞 | Thermo Fisher Scientific

Explore curated resources on phosphoramidite chemistry and oligonucleotide synthesis for diagnostic and therapeutic applications. Access articles, videos, technical notes, and other scientific content to support development from early research through manufacturing.

Teach me in 10

Oligonucleotide therapeutics

Hear our conversation with Technology Networks on the basics of oligonucleotide therapeutics, their trends and challenges, and what to consider during their development.

Articles

Oligonucleotide therapeutics basics

Get answers to common questions about oligonucleotide therapeutics and how Thermo Fisher can help oligo drug developers.

Phosphoramidite considerations

Learn about key considerations for phosphoramidites in synthesis of oligonucleotides for diagnostic and therapeutic applications.

eBooks

DNA and a scientist looking through a microscope

Oligonucleotide therapeutics

Find resources and tools to help you accelerate your oligo therapeutics to market.

Infographics

Rendering of two scientists building an oligo

Building synthetic oligonucleotides with phosphoramidites

Learn about the basics and usage of phosphoramidites in oligo synthesis for diagnostic and therapeutic applications.

Resources and tools for oligo therapeutics development

Read about common types, milestones, research areas, and more about oligonucleotide therapeutics.

Posters

Amidite structure with potential impurity

Impurity analysis of phosphoramidites for producing oligo therapeutics

Review the synthesis of phosphoramidites and identify sources of potential impurities that may impact manufacturing of oligonucleotides for therapeutic applications.

Therapeutic oligo quality: Profiling and controlling for raw material impurities

Understand the impact of raw materials on phosphoramidite chemistry, including impurity profile, and subsequent effects to oligo purity.

Technical notes

phosphoramidite impurity classification table

Classification and characterization of impurities for oligo therapeutics

Learn about the risk mitigation strategies for entering clinical phases with oligonucleotide therapeutics and measures for a better development outcome.