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Invitrogen
Bovine PrP (aa 146-159) Synthetic Peptide
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产品信息
PEP-051
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-051 is a 14 amino acid synthetic peptide whose sequence corresponds to residues 146-159 of bovine Prion Protein. The sequence of this peptide is (amino to carboxy terminus): S146-R-P-L-I-H-F-G-S-D-Y-E-D-R159
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and prion protein, catalog # MA1-750. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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