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RP-77543 is a purified, truncated recombinant human ADAMTS1 protein expressed in insect cells.
RP-77543 may be used as a control with corresponding anti-ADAMTS1 antibodies. ADAMTS1 is inhibited by chelators of divalent cations such as EDTA and catechin gallate esters.
ADAMTS-1 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
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