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Invitrogen
Human CCDC14 (aa 205-290) Control Fragment Recombinant Protein
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产品信息
RP-96447
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
IIYQALCEHVQTQMSLMNDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQTDGNSQFASQG
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (67%), Rat (67%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57212. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
CCDC14 (Coiled-Coil Domain-Containing 14) is a gene that encodes a protein involved in ciliary function and cellular division processes. This protein contains coiled-coil domains that facilitate protein-protein interactions crucial for the assembly and stabilization of microtubule structures within the cell. Research indicates that CCDC14 is essential for proper ciliogenesis, the process by which cells form cilia, which are vital for cell motility, fluid movement, and signal transduction. Additionally, studies have revealed its significant role in the regulation of cell cycle progression and cytokinesis. CCDC14 is required for the accurate segregation of chromosomes during cell division, ensuring genomic stability. Mutations or dysregulation of CCDC14 can lead to ciliopathies and other cellular dysfunctions, highlighting its critical role in maintaining normal cellular activities and its potential implications in various diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coiled-coil domain-containing protein 14
基因别名: CCDC14
UniProt ID: (Human) B8ZZ58
Entrez Gene ID: (Human) 64770
